KCC2 overexpression prevents the paradoxical seizure-promoting action of somatic inhibition
Previous studies have highlighted a paradoxical role of perisomatic-targeting parvalbumin-positive (PV+) interneurons in ictogenesis. Here, authors used an acute in vivo model of focal cortical seizures in awake behaving mice to show that photo-depolarization of PV+ interneurons rapidly switches fro...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2019-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-08933-4 |