Hepatic gene therapy rescues high-fat diet responses in circadian Clock mutant mice

Hepatic gene therapy rescues high-fat diet responses in circadian Clock mutant mice

Objective: Circadian Clock gene mutant mice show dampened 24-h feeding rhythms and an increased sensitivity to high-fat diet (HFD) feeding. Restricting HFD access to the dark phase counteracts its obesogenic effect in wild-type mice. The extent to which altered feeding rhythms are causative for the...

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Bibliographic Details
Main Authors: Judit Meyer-Kovac, Isa Kolbe, Lea Ehrhardt, Alexei Leliavski, Jana Husse, Gabriela Salinas, Thomas Lingner, Anthony H. Tsang, Johanna L. Barclay, Henrik Oster
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Molecular Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877817301722

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http://www.sciencedirect.com/science/article/pii/S2212877817301722

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