JMJD6 Dysfunction Due to Iron Deficiency in Preeclampsia Disrupts Fibronectin Homeostasis Resulting in Diminished Trophoblast Migration

JMJD6 Dysfunction Due to Iron Deficiency in Preeclampsia Disrupts Fibronectin Homeostasis Resulting in Diminished Trophoblast Migration

The mechanisms contributing to excessive fibronectin in preeclampsia, a pregnancy-related disorder, remain unknown. Herein, we investigated the role of JMJD6, an O2- and Fe2+-dependent enzyme, in mediating placental fibronectin processing and function. MALDI-TOF identified fibronectin as a novel tar...

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Bibliographic Details
Main Authors: Sruthi Alahari, Abby Farrell, Leonardo Ermini, Chanho Park, Julien Sallais, Sarah Roberts, Taylor Gillmore, Michael Litvack, Martin Post, Isabella Caniggia
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
fibronectin
iron
JMJD6
pMSCs
preeclampsia
trophoblast migration
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.652607/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.652607/full

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