Combinatory FK506 and Minocycline Treatment Alleviates Prion-Induced Neurodegenerative Events via Caspase-Mediated MAPK-NRF2 Pathway

Combinatory FK506 and Minocycline Treatment Alleviates Prion-Induced Neurodegenerative Events via Caspase-Mediated MAPK-NRF2 Pathway

Transcription factors play a significant role during the symptomatic onset and progression of prion diseases. We previously showed the immunomodulatory and nuclear factor of activated T cells’ (NFAT) suppressive effects of an immunosuppressant, FK506, in the symptomatic stage and an antibi...

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Bibliographic Details
Main Authors: Syed Zahid Ali Shah, Deming Zhao, Giulio Taglialatela, Tariq Hussain, Haodi Dong, Naveed Sabir, Mazhar Hussain Mangi, Wei Wu, Mengyu Lai, Xixi Zhang, Yuhan Duan, Lu Wang, Xiangmei Zhou, Lifeng Yang
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
transcription factors
astrogliosis
nuclear factor of activated T-cells (NFAT)
phosphorylated mitogen-activated protein kinase (MAPK) p38
nuclear factor kappa-b (NF-kB)
phosphorylated cAMP response element-binding protein (pCREB)
phosphorylated Bcl2-associated death promoter (pBAD)
nuclear factor–erythroid2-related factor-2 (NRF2)
heme oxygenase 1 (HO-1)
Online Access:http://www.mdpi.com/1422-0067/20/5/1144

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