Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS
Here, the authors perform transcriptional profiling on tracheal aspirates of adults requiring mechanical ventilation for SARS-CoV2-induced acute respiratory distress syndrome (ARDS) and identify a dysregulated host response predicted to predicted to be potentially modulated by dexamethasone.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2021-08-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-25040-5 |
| id |
doaj-5e15572a162f473290932a34e9eb1ffa |
|---|---|
| record_format |
Article |
| spelling |
doaj-5e15572a162f473290932a34e9eb1ffa2021-08-29T11:38:02ZengNature Publishing GroupNature Communications2041-17232021-08-0112111010.1038/s41467-021-25040-5Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDSAartik Sarma0Stephanie A. Christenson1Ashley Byrne2Eran Mick3Angela Oliveira Pisco4Catherine DeVoe5Thomas Deiss6Rajani Ghale7Beth Shoshana Zha8Alexandra Tsitsiklis9Alejandra Jauregui10Farzad Moazed11Angela M. Detweiler12Natasha Spottiswoode13Pratik Sinha14Norma Neff15Michelle Tan16Paula Hayakawa Serpa17Andrew Willmore18K. Mark Ansel19Jennifer G. Wilson20Aleksandra Leligdowicz21Emily R. Siegel22Marina Sirota23Joseph L. DeRisi24Michael A. Matthay25COMET ConsortiumCarolyn M. Hendrickson26Kirsten N. Kangelaris27Matthew F. Krummel28Prescott G. Woodruff29David J. Erle30Carolyn S. Calfee31Charles R. Langelier32Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of CaliforniaDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of CaliforniaChan Zuckerberg BiohubDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of CaliforniaChan Zuckerberg BiohubDivision of Infectious Diseases, University of CaliforniaChan Zuckerberg BiohubDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of CaliforniaDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of CaliforniaDivision of Infectious Diseases, University of CaliforniaDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of CaliforniaDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of CaliforniaDivision of Infectious Diseases, University of CaliforniaDepartment of Medicine, University of CaliforniaDepartment of Anesthesia, Washington UniversityChan Zuckerberg BiohubChan Zuckerberg BiohubDivision of Infectious Diseases, University of CaliforniaDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of CaliforniaDepartment of Microbiology and Immunology, University of CaliforniaDepartment of Emergency Medicine, Stanford UniversityDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of CaliforniaSchool of Medicine, University of CaliforniaDivision of Rheumatology, University of CaliforniaChan Zuckerberg BiohubDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of CaliforniaDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of CaliforniaDepartment of Medicine, University of CaliforniaDepartment of Pathology, University of CaliforniaDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of CaliforniaDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of CaliforniaDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of CaliforniaChan Zuckerberg BiohubHere, the authors perform transcriptional profiling on tracheal aspirates of adults requiring mechanical ventilation for SARS-CoV2-induced acute respiratory distress syndrome (ARDS) and identify a dysregulated host response predicted to predicted to be potentially modulated by dexamethasone.https://doi.org/10.1038/s41467-021-25040-5 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Aartik Sarma Stephanie A. Christenson Ashley Byrne Eran Mick Angela Oliveira Pisco Catherine DeVoe Thomas Deiss Rajani Ghale Beth Shoshana Zha Alexandra Tsitsiklis Alejandra Jauregui Farzad Moazed Angela M. Detweiler Natasha Spottiswoode Pratik Sinha Norma Neff Michelle Tan Paula Hayakawa Serpa Andrew Willmore K. Mark Ansel Jennifer G. Wilson Aleksandra Leligdowicz Emily R. Siegel Marina Sirota Joseph L. DeRisi Michael A. Matthay COMET Consortium Carolyn M. Hendrickson Kirsten N. Kangelaris Matthew F. Krummel Prescott G. Woodruff David J. Erle Carolyn S. Calfee Charles R. Langelier |
| spellingShingle |
Aartik Sarma Stephanie A. Christenson Ashley Byrne Eran Mick Angela Oliveira Pisco Catherine DeVoe Thomas Deiss Rajani Ghale Beth Shoshana Zha Alexandra Tsitsiklis Alejandra Jauregui Farzad Moazed Angela M. Detweiler Natasha Spottiswoode Pratik Sinha Norma Neff Michelle Tan Paula Hayakawa Serpa Andrew Willmore K. Mark Ansel Jennifer G. Wilson Aleksandra Leligdowicz Emily R. Siegel Marina Sirota Joseph L. DeRisi Michael A. Matthay COMET Consortium Carolyn M. Hendrickson Kirsten N. Kangelaris Matthew F. Krummel Prescott G. Woodruff David J. Erle Carolyn S. Calfee Charles R. Langelier Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS Nature Communications |
| author_facet |
Aartik Sarma Stephanie A. Christenson Ashley Byrne Eran Mick Angela Oliveira Pisco Catherine DeVoe Thomas Deiss Rajani Ghale Beth Shoshana Zha Alexandra Tsitsiklis Alejandra Jauregui Farzad Moazed Angela M. Detweiler Natasha Spottiswoode Pratik Sinha Norma Neff Michelle Tan Paula Hayakawa Serpa Andrew Willmore K. Mark Ansel Jennifer G. Wilson Aleksandra Leligdowicz Emily R. Siegel Marina Sirota Joseph L. DeRisi Michael A. Matthay COMET Consortium Carolyn M. Hendrickson Kirsten N. Kangelaris Matthew F. Krummel Prescott G. Woodruff David J. Erle Carolyn S. Calfee Charles R. Langelier |
| author_sort |
Aartik Sarma |
| title |
Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS |
| title_short |
Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS |
| title_full |
Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS |
| title_fullStr |
Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS |
| title_full_unstemmed |
Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS |
| title_sort |
tracheal aspirate rna sequencing identifies distinct immunological features of covid-19 ards |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-08-01 |
| description |
Here, the authors perform transcriptional profiling on tracheal aspirates of adults requiring mechanical ventilation for SARS-CoV2-induced acute respiratory distress syndrome (ARDS) and identify a dysregulated host response predicted to predicted to be potentially modulated by dexamethasone. |
| url |
https://doi.org/10.1038/s41467-021-25040-5 |
| work_keys_str_mv |
AT aartiksarma trachealaspiraternasequencingidentifiesdistinctimmunologicalfeaturesofcovid19ards AT stephanieachristenson trachealaspiraternasequencingidentifiesdistinctimmunologicalfeaturesofcovid19ards AT ashleybyrne trachealaspiraternasequencingidentifiesdistinctimmunologicalfeaturesofcovid19ards AT eranmick trachealaspiraternasequencingidentifiesdistinctimmunologicalfeaturesofcovid19ards AT angelaoliveirapisco trachealaspiraternasequencingidentifiesdistinctimmunologicalfeaturesofcovid19ards AT catherinedevoe trachealaspiraternasequencingidentifiesdistinctimmunologicalfeaturesofcovid19ards AT thomasdeiss trachealaspiraternasequencingidentifiesdistinctimmunologicalfeaturesofcovid19ards AT rajanighale trachealaspiraternasequencingidentifiesdistinctimmunologicalfeaturesofcovid19ards AT bethshoshanazha trachealaspiraternasequencingidentifiesdistinctimmunologicalfeaturesofcovid19ards AT alexandratsitsiklis trachealaspiraternasequencingidentifiesdistinctimmunologicalfeaturesofcovid19ards AT alejandrajauregui trachealaspiraternasequencingidentifiesdistinctimmunologicalfeaturesofcovid19ards AT farzadmoazed trachealaspiraternasequencingidentifiesdistinctimmunologicalfeaturesofcovid19ards AT angelamdetweiler trachealaspiraternasequencingidentifiesdistinctimmunologicalfeaturesofcovid19ards AT natashaspottiswoode trachealaspiraternasequencingidentifiesdistinctimmunologicalfeaturesofcovid19ards AT pratiksinha trachealaspiraternasequencingidentifiesdistinctimmunologicalfeaturesofcovid19ards AT normaneff trachealaspiraternasequencingidentifiesdistinctimmunologicalfeaturesofcovid19ards AT michelletan trachealaspiraternasequencingidentifiesdistinctimmunologicalfeaturesofcovid19ards AT paulahayakawaserpa trachealaspiraternasequencingidentifiesdistinctimmunologicalfeaturesofcovid19ards AT andrewwillmore trachealaspiraternasequencingidentifiesdistinctimmunologicalfeaturesofcovid19ards AT kmarkansel trachealaspiraternasequencingidentifiesdistinctimmunologicalfeaturesofcovid19ards AT jennifergwilson trachealaspiraternasequencingidentifiesdistinctimmunologicalfeaturesofcovid19ards AT aleksandraleligdowicz trachealaspiraternasequencingidentifiesdistinctimmunologicalfeaturesofcovid19ards AT emilyrsiegel trachealaspiraternasequencingidentifiesdistinctimmunologicalfeaturesofcovid19ards AT marinasirota trachealaspiraternasequencingidentifiesdistinctimmunologicalfeaturesofcovid19ards AT josephlderisi trachealaspiraternasequencingidentifiesdistinctimmunologicalfeaturesofcovid19ards AT michaelamatthay trachealaspiraternasequencingidentifiesdistinctimmunologicalfeaturesofcovid19ards AT cometconsortium trachealaspiraternasequencingidentifiesdistinctimmunologicalfeaturesofcovid19ards AT carolynmhendrickson trachealaspiraternasequencingidentifiesdistinctimmunologicalfeaturesofcovid19ards AT kirstennkangelaris trachealaspiraternasequencingidentifiesdistinctimmunologicalfeaturesofcovid19ards AT matthewfkrummel trachealaspiraternasequencingidentifiesdistinctimmunologicalfeaturesofcovid19ards AT prescottgwoodruff trachealaspiraternasequencingidentifiesdistinctimmunologicalfeaturesofcovid19ards AT davidjerle trachealaspiraternasequencingidentifiesdistinctimmunologicalfeaturesofcovid19ards AT carolynscalfee trachealaspiraternasequencingidentifiesdistinctimmunologicalfeaturesofcovid19ards AT charlesrlangelier trachealaspiraternasequencingidentifiesdistinctimmunologicalfeaturesofcovid19ards |
| _version_ |
1721186581831745536 |