Glycan remodeled erythrocytes facilitate antigenic characterization of recent A/H3N2 influenza viruses

Glycan remodeled erythrocytes facilitate antigenic characterization of recent A/H3N2 influenza viruses

Here, Broszeit et al. show that circulating A/H3N2 viruses have evolved binding specificity to α2,6-sialosides on extended LacNAc moieties and therefore cannot agglutinate erythrocytes. Applying glycan remodeling allows to install functional receptors on erythrocytes and promotes identification of n...

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Bibliographic Details
Main Authors: Frederik Broszeit, Rosanne J. van Beek, Luca Unione, Theo M. Bestebroer, Digantkumar Chapla, Jeong-Yeh Yang, Kelley W. Moremen, Sander Herfst, Ron A. M. Fouchier, Robert P. de Vries, Geert-Jan Boons
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25713-1

Internet

https://doi.org/10.1038/s41467-021-25713-1

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