Polyclonal Expansion of NKG2C+ NK Cells in TAP-deficient Patients

Polyclonal Expansion of NKG2C+ NK Cells in TAP-deficient Patients

Adaptive natural killer (NK) cell responses to human cytomegalovirus (CMV) infection are characterized by the expansion of NKG2C+ NK cells expressing self-specific inhibitory killer-cell immunoglobulin-like receptors (KIRs). Here, we set out to study the HLA class I-dependency of such NKG2C+ NK cell...

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Bibliographic Details
Main Authors: vivien eBeziat, Marwan eSleiman, Jodie eGoodridge, Mari eKaarbo, lisa eliu, Halvor eRollag, hans-gustaf eljunggren, jacques ezimmer, Karl-Johan eMalmberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-10-01
Series:Frontiers in Immunology
Subjects:
Adaptive Immunity
Cytomegalovirus Infections
natural killer (NK) cells
Killer cell immunoglobulin-like receptor
Transporter associated with antigen processing (TAP)
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00507/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00507/full

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