A Single Residue Mutation in the Gαq Subunit of the G Protein Complex Causes Blindness in Drosophila

A Single Residue Mutation in the Gαq Subunit of the G Protein Complex Causes Blindness in Drosophila

Heterotrimeric G proteins play central roles in many signaling pathways, including the phototransduction cascade in animals. However, the degree of involvement of the G protein subunit Gαq is not clear since animals with previously reported strong loss-of-function mutations remain responsive to ligh...

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Bibliographic Details
Main Authors: Jinguo Cao, Murali K. Bollepalli, Yuhui Hu, Jin Zhang, Qiang Li, Hongmei Li, Hua Chang, Feng Xiao, Roger C. Hardie, Yikang S. Rong, Wen Hu
Format: Article
Language:English
Published: Oxford University Press 2018-01-01
Series:G3: Genes, Genomes, Genetics
Subjects:
phototransduction
photoreceptor
G protein
ERG
Gαq
Gα PLC interaction
light-induced retinal degeneration
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.117.300340

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http://g3journal.org/lookup/doi/10.1534/g3.117.300340

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