A post-burst after depolarization is mediated by group i metabotropic glutamate receptor-dependent upregulation of Ca(v)2.3 R-type calcium channels in CA1 pyramidal neurons.

A post-burst after depolarization is mediated by group i metabotropic glutamate receptor-dependent upregulation of Ca(v)2.3 R-type calcium channels in CA1 pyramidal neurons.

Activation of group I metabotropic glutamate receptors (subtypes mGluR1 and mGluR5) regulates neural activity in a variety of ways. In CA1 pyramidal neurons, activation of group I mGluRs eliminates the post-burst afterhyperpolarization (AHP) and produces an afterdepolarization (ADP) in its place. He...

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Bibliographic Details
Main Authors: Jin-Yong Park, Stefan Remy, Juan Varela, Donald C Cooper, Sungkwon Chung, Ho-Won Kang, Jung-Ha Lee, Nelson Spruston
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-11-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC2982802?pdf=render

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http://europepmc.org/articles/PMC2982802?pdf=render

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