C-Reactive Protein Stimulates Nicotinic Acetylcholine Receptors to Control ATP-Mediated Monocytic Inflammasome Activation

C-Reactive Protein Stimulates Nicotinic Acetylcholine Receptors to Control ATP-Mediated Monocytic Inflammasome Activation

Blood levels of the acute phase reactant C-reactive protein (CRP) are frequently measured as a clinical marker for inflammation, but the biological functions of CRP are still controversial. CRP is a phosphocholine (PC)-binding pentraxin, mainly produced in the liver in response to elevated levels of...

Full description

Bibliographic Details
Main Authors: Katrin Richter, Sabrina Sagawe, Andreas Hecker, Mira Küllmar, Ingolf Askevold, Jelena Damm, Sarah Heldmann, Michael Pöhlmann, Sophie Ruhrmann, Michael Sander, Klaus-Dieter Schlüter, Sigrid Wilker, Inke R. König, Wolfgang Kummer, Winfried Padberg, Arik J. Hone, J. Michael McIntosh, Anna Teresa Zakrzewicz, Christian Koch, Veronika Grau
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
C-reactive protein
interleukin-1β
NLRP3 inflammasome
monocytes
nicotinic acetylcholine receptors
sterile inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01604/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01604/full

Similar Items