Role of TLR4-p38 MAPK-Hsp27 signal pathway in LPS-induced pulmonary epithelial hyperpermeability

Abstract Background The breakdown of alveolar barrier dysfunction contributes to Lipopolysaccharide stimulated pulmonary edema and acute lung injury. Actin cytoskeleton has been implicated to be critical in regulation of epithelial barrier. Here, we performed in vivo and in vitro study to investigat...

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Bibliographic Details
Main Authors: Weiju Wang, Jie Weng, Lei Yu, Qiaobing Huang, Yong Jiang, Xiaohua Guo
Format: Article
Language:English
Published: BMC 2018-11-01
Series:BMC Pulmonary Medicine
Subjects:
ALI
LPS
Online Access:http://link.springer.com/article/10.1186/s12890-018-0735-0