Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds.

Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds.

In 2010 the identities of thousands of anti-Plasmodium compounds were released publicly to facilitate malaria drug development. Understanding these compounds' mechanisms of action--i.e., the specific molecular targets by which they kill the parasite--would further facilitate the drug developmen...

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Bibliographic Details
Main Authors: Gregory J Crowther, Heidi K Hillesland, Katelyn R Keyloun, Molly C Reid, Maria Jose Lafuente-Monasterio, Sonja Ghidelli-Disse, Stephen E Leonard, Panqing He, Jackson C Jones, Mallory M Krahn, Jack S Mo, Kartheek S Dasari, Anna M W Fox, Markus Boesche, Majida El Bakkouri, Kasey L Rivas, Didier Leroy, Raymond Hui, Gerard Drewes, Dustin J Maly, Wesley C Van Voorhis, Kayode K Ojo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4774911?pdf=render

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http://europepmc.org/articles/PMC4774911?pdf=render

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