Application of Single Molecule Fluorescence Microscopy to Characterize the Penetration of a Large Amphiphilic Molecule in the Stratum Corneum of Human Skin

Application of Single Molecule Fluorescence Microscopy to Characterize the Penetration of a Large Amphiphilic Molecule in the Stratum Corneum of Human Skin

We report here on the application of laser-based single molecule total internal reflection fluorescence microscopy (TIRFM) to study the penetration of molecules through the skin. Penetration of topically applied drug molecules is often observed to be limited by the size of the respective drug. Howev...

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Bibliographic Details
Main Authors: Pierre Volz, Alexander Boreham, Alexander Wolf, Tai-Yang Kim, Jens Balke, Janna Frombach, Sabrina Hadam, Zahra Afraz, Fiorenza Rancan, Ulrike Blume-Peytavi, Annika Vogt, Ulrike Alexiev
Format: Article
Language:English
Published: MDPI AG 2015-03-01
Series:International Journal of Molecular Sciences
Subjects:
single molecule fluorescence microscopy
total internal reflection fluorescence microscopy
single particle tracking
skin penetration
penetration pathways
stratum corneum
tape stripping
Online Access:http://www.mdpi.com/1422-0067/16/4/6960

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http://www.mdpi.com/1422-0067/16/4/6960

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