Postnatal PPARdelta activation and myostatin inhibition exert distinct yet complimentary effects on the metabolic profile of obese insulin-resistant mice.

Postnatal PPARdelta activation and myostatin inhibition exert distinct yet complimentary effects on the metabolic profile of obese insulin-resistant mice.

BACKGROUND: Interventions for T2DM have in part aimed to mimic exercise. Here, we have compared the independent and combined effects of a PPARdelta agonist and endurance training mimetic (GW501516) and a myostatin antibody and resistance training mimetic (PF-879) on metabolic and performance outcome...

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Bibliographic Details
Main Authors: Barbara L Bernardo, Timothy S Wachtmann, Patricia G Cosgrove, Max Kuhn, Alan C Opsahl, Kyle M Judkins, Thomas B Freeman, John R Hadcock, Nathan K LeBrasseur
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2892469?pdf=render

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http://europepmc.org/articles/PMC2892469?pdf=render

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