Comparative analysis of mRNA and protein degradation in prostate tissues indicates high stability of proteins

Comparative analysis of mRNA and protein degradation in prostate tissues indicates high stability of proteins

Protein degradation in clinical samples is largely unexplored. Here, the authors analyze the transcriptome and proteome of clinical tissue samples and develop an algorithm to assess protein degradation, showing that protein degradation is negligible in most tissue samples and does not correlate with...

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Bibliographic Details
Main Authors: Wenguang Shao, Tiannan Guo, Nora C. Toussaint, Peng Xue, Ulrich Wagner, Li Li, Konstantina Charmpi, Yi Zhu, Jianmin Wu, Marija Buljan, Rui Sun, Dorothea Rutishauser, Thomas Hermanns, Christian Daniel Fankhauser, Cedric Poyet, Jelena Ljubicic, Niels Rupp, Jan H. Rüschoff, Qing Zhong, Andreas Beyer, Jiafu Ji, Ben C. Collins, Yansheng Liu, Gunnar Rätsch, Peter J. Wild, Ruedi Aebersold
Format: Article
Language:English
Published: Nature Publishing Group 2019-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10513-5

Internet

https://doi.org/10.1038/s41467-019-10513-5

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