Glycogen Storage Disease Type Ia in Canines: A Model for Human Metabolic and Genetic Liver Disease

Glycogen Storage Disease Type Ia in Canines: A Model for Human Metabolic and Genetic Liver Disease

A canine model of Glycogen storage disease type Ia (GSDIa) is described. Affected dogs are homozygous for a previously described M121I mutation resulting in a deficiency of glucose-6-phosphatase-α. Metabolic, clinicopathologic, pathologic, and clinical manifestations of GSDIa observed in this model...

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Bibliographic Details
Main Authors: Andrew Specht, Laurie Fiske, Kirsten Erger, Travis Cossette, John Verstegen, Martha Campbell-Thompson, Maggie B. Struck, Young Mok Lee, Janice Y. Chou, Barry J. Byrne, Catherine E. Correia, Cathryn S. Mah, David A. Weinstein, Thomas J. Conlon
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:Journal of Biomedicine and Biotechnology
Online Access:http://dx.doi.org/10.1155/2011/646257

Internet

http://dx.doi.org/10.1155/2011/646257

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