Mitochondrial electron transport is the cellular target of the oncology drug elesclomol.

Mitochondrial electron transport is the cellular target of the oncology drug elesclomol.

Elesclomol is a first-in-class investigational drug currently undergoing clinical evaluation as a novel cancer therapeutic. The potent antitumor activity of the compound results from the elevation of reactive oxygen species (ROS) and oxidative stress to levels incompatible with cellular survival. Ho...

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Bibliographic Details
Main Authors: Ronald K Blackman, Kahlin Cheung-Ong, Marinella Gebbia, David A Proia, Suqin He, Jane Kepros, Aurelie Jonneaux, Philippe Marchetti, Jerome Kluza, Patricia E Rao, Yumiko Wada, Guri Giaever, Corey Nislow
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3256171?pdf=render

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http://europepmc.org/articles/PMC3256171?pdf=render

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