Intermedin in Paraventricular Nucleus Attenuates Ang II-Induced Sympathoexcitation through the Inhibition of NADPH Oxidase-Dependent ROS Generation in Obese Rats with Hypertension

Intermedin in Paraventricular Nucleus Attenuates Ang II-Induced Sympathoexcitation through the Inhibition of NADPH Oxidase-Dependent ROS Generation in Obese Rats with Hypertension

Increased reactive oxygen species (ROS) induced by angiotensin II (Ang II) in the paraventricular nucleus (PVN) play a critical role in sympathetic overdrive in hypertension (OH). Intermedin (IMD), a bioactive peptide, has extensive clinically prospects in preventing and treating cardiovascular dise...

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Bibliographic Details
Main Authors: Ying Kang, Lei Ding, Hangbing Dai, Fangzheng Wang, Hong Zhou, Qing Gao, Xiaoqing Xiong, Feng Zhang, Tianrun Song, Yan Yuan, Guoqing Zhu, Yebo Zhou
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:International Journal of Molecular Sciences
Subjects:
intermedin
paraventricular nucleus
sympathoexcitation
NADPH oxidase
angiotensin II
obesity-related hypertension
Online Access:https://www.mdpi.com/1422-0067/20/17/4217

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https://www.mdpi.com/1422-0067/20/17/4217

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