Col4a1 mutation generates vascular abnormalities correlated with neuronal damage in a mouse model of HANAC syndrome

Col4a1 mutation generates vascular abnormalities correlated with neuronal damage in a mouse model of HANAC syndrome

The HANAC syndrome is caused by mutations in the gene coding for collagen4a1, a major component of blood vessel basement membranes. Ocular symptoms include an increase in blood vessel tortuosity and occasional hemorrhages. To examine how vascular defects can affect neuronal function, we analyzed the...

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Bibliographic Details
Main Authors: Alix Trouillet, Henri Lorach, Elisabeth Dubus, Brahim El Mathari, Ivana Ivkovic, Julie Dégardin, Manuel Simonutti, Michel Paques, Xavier Guillonneau, Florian Sennlaub, José-Alain Sahel, Pierre Ronco, Emmanuelle Plaisier, Serge Picaud
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:Neurobiology of Disease
Subjects:
Collagen
Retinal damage
Mouse model
Vascular permeability
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116302959

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http://www.sciencedirect.com/science/article/pii/S0969996116302959

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