Synthesis and Pharmacological Characterization of 2‑Aminoethyl Diphenylborinate (2-APB) Derivatives for Inhibition of Store-Operated Calcium Entry (SOCE) in MDA-MB-231 Breast Cancer Cells

Synthesis and Pharmacological Characterization of 2‑Aminoethyl Diphenylborinate (2-APB) Derivatives for Inhibition of Store-Operated Calcium Entry (SOCE) in MDA-MB-231 Breast Cancer Cells

Calcium ions regulate a wide array of physiological functions including cell differentiation, proliferation, muscle contraction, neurotransmission, and fertilization. The endoplasmic reticulum (ER) is the major intracellular Ca<sup>2+</sup> store and cellular events that induce ER store...

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Bibliographic Details
Main Authors: Achille Schild, Rajesh Bhardwaj, Nicolas Wenger, Dominic Tscherrig, Palanivel Kandasamy, Jan Dernič, Roland Baur, Christine Peinelt, Matthias A. Hediger, Martin Lochner
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
store-operated calcium entry
inhibitors
synthetic chemistry
2-APB
structure–activity relationship
breast cancer cells
Online Access:https://www.mdpi.com/1422-0067/21/16/5604

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https://www.mdpi.com/1422-0067/21/16/5604

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