Tolerogenic versus Inflammatory Activity of Peripheral Blood Monocytes and Dendritic Cells Subpopulations in Systemic Lupus Erythematosus

Abnormalities in monocytes and in peripheral blood dendritic cells (DC) subsets have been reported in systemic lupus erythematosus (SLE). We aim to clarify the tolerogenic or inflammatory role of these cells based on ICOSL or IFN-α and chemokine mRNA expression, respectively, after cell purification...

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Bibliographic Details
Main Authors: Tiago Carvalheiro, Ana Rodrigues, Ana Lopes, Luís Inês, Isabel Velada, Andreia Ribeiro, António Martinho, José A. P. Silva, Maria L. Pais, Artur Paiva
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Clinical and Developmental Immunology
Online Access:http://dx.doi.org/10.1155/2012/934161