Joint Modeling of Immune Reconstitution Post Haploidentical Stem Cell Transplantation in Pediatric Patients With Acute Leukemia Comparing CD34+-Selected to CD3/CD19-Depleted Grafts in a Retrospective Multicenter Study

Joint Modeling of Immune Reconstitution Post Haploidentical Stem Cell Transplantation in Pediatric Patients With Acute Leukemia Comparing CD34+-Selected to CD3/CD19-Depleted Grafts in a Retrospective Multicenter Study

Rapid immune reconstitution (IR) following stem cell transplantation (SCT) is essential for a favorable outcome. The optimization of graft composition should not only enable a sufficient IR but also improve graft vs. leukemia/tumor effects, overcome infectious complications and, finally, improve pat...

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Bibliographic Details
Main Authors: Emilia Salzmann-Manrique, Melanie Bremm, Sabine Huenecke, Milena Stech, Andreas Orth, Matthias Eyrich, Ansgar Schulz, Ruth Esser, Thomas Klingebiel, Peter Bader, Eva Herrmann, Ulrike Koehl
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Immunology
Subjects:
immune reconstitution
allogeneic stem cell transplantation
CD34 selection
CD3/19 depletion
children
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01841/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.01841/full

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