A PI3-kinase-mediated negative feedback regulates neuronal excitability.
Use-dependent downregulation of neuronal activity (negative feedback) can act as a homeostatic mechanism to maintain neuronal activity at a particular specified value. Disruption of this negative feedback might lead to neurological pathologies, such as epilepsy, but the precise mechanisms by which t...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2008-11-01
|
| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC2581892?pdf=render |