Diverse Phenotypes and Specific Transcription Patterns in Twenty Mouse Lines with Ablated LincRNAs.

Diverse Phenotypes and Specific Transcription Patterns in Twenty Mouse Lines with Ablated LincRNAs.

In a survey of 20 knockout mouse lines designed to examine the biological functions of large intergenic non-coding RNAs (lincRNAs), we have found a variety of phenotypes, ranging from perinatal lethality to defects associated with premature aging and morphological and functional abnormalities in the...

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Bibliographic Details
Main Authors: Ka-Man Venus Lai, Guochun Gong, Amanda Atanasio, José Rojas, Joseph Quispe, Julita Posca, Derek White, Mei Huang, Daria Fedorova, Craig Grant, Lawrence Miloscio, Gustavo Droguett, William T Poueymirou, Wojtek Auerbach, George D Yancopoulos, David Frendewey, John Rinn, David M Valenzuela
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4409293?pdf=render

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http://europepmc.org/articles/PMC4409293?pdf=render

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