Activation of carbonic anhydrases from human brain by amino alcohol oxime ethers: towards human carbonic anhydrase VII selective activators

Activation of carbonic anhydrases from human brain by amino alcohol oxime ethers: towards human carbonic anhydrase VII selective activators

The synthesis and carbonic anhydrase (CA; EC 4.2.1.1) activating effects of a series of oxime ether-based amino alcohols towards four human (h) CA isoforms expressed in human brain, hCA I, II, IV and VII, are described. Most investigated amino alcohol derivatives induced a consistent activation of t...

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Bibliographic Details
Main Authors: Alessio Nocentini, Doretta Cuffaro, Lidia Ciccone, Elisabetta Orlandini, Susanna Nencetti, Elisa Nuti, Armando Rossello, Claudiu T. Supuran
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
metalloenzyme
activation
selectivity
cns-disease
cognition
Online Access:http://dx.doi.org/10.1080/14756366.2020.1838501

Internet

http://dx.doi.org/10.1080/14756366.2020.1838501

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