Inactivation of sphingosine-1-phosphate receptor 2 (S1PR2) decreases demyelination and enhances remyelination in animal models of multiple sclerosis

Inactivation of sphingosine-1-phosphate receptor 2 (S1PR2) decreases demyelination and enhances remyelination in animal models of multiple sclerosis

Multiple sclerosis is an inflammatory disease of the central nervous system (CNS) in which multiple sites of blood-brain barrier (BBB) disruption, focal inflammation, demyelination and tissue destruction are the hallmarks. Here we show that sphingosine-1-phosphate receptor 2 (S1PR2) has a negative r...

Full description

Bibliographic Details
Main Authors: Maryam S. Seyedsadr, Oliver Weinmann, Ana Amorim, Benjamin V. Ineichen, Matteo Egger, Javad Mirnajafi-Zadeh, Burkhard Becher, Mohammad Javan, Martin E. Schwab
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:Neurobiology of Disease
Subjects:
S1PR2 inactivation
JTE-013
Lysolecithin
Experimental autoimmune encephalitis
Blood brain barrier
Nogo-A
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118307496

Internet

http://www.sciencedirect.com/science/article/pii/S0969996118307496

Similar Items