Reduced hypertrophy in vitro after chondrogenic differentiation of adult human mesenchymal stem cells following adenoviral SOX9 gene delivery

Reduced hypertrophy in vitro after chondrogenic differentiation of adult human mesenchymal stem cells following adenoviral SOX9 gene delivery

Abstract Background Mesenchymal stem cell (MSC) based-treatments of cartilage injury are promising but impaired by high levels of hypertrophy after chondrogenic induction with several bone morphogenetic protein superfamily members (BMPs). As an alternative, this study investigates the chondrogenic i...

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Bibliographic Details
Main Authors: M. Weissenberger, M. H. Weissenberger, F. Gilbert, J. Groll, C. H. Evans, A. F. Steinert
Format: Article
Language:English
Published: BMC 2020-02-01
Series:BMC Musculoskeletal Disorders
Subjects:
Mesenchymal stem cell
Cartilage
SOX9
Gene therapy
Chondrogenesis
Hypertrophy
Online Access:http://link.springer.com/article/10.1186/s12891-020-3137-4

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http://link.springer.com/article/10.1186/s12891-020-3137-4

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