Spinal Antinociceptive Action of Amiloride and Its Interaction with Tizanidine in the Rat Formalin Test
BACKGROUND: Amiloride has been reported to produce a wide variety of actions, thereby affecting several ionic channels and a multitude of receptors and enzymes. Intrathecal α2-adrenergic receptor agonists produce pronounced analgesia, and amiloride modulates α2-adrenergic receptor agonist binding an...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2015-01-01
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| Series: | Pain Research and Management |
| Online Access: | http://dx.doi.org/10.1155/2015/902914 |