Enhancement of Autophagy by Simvastatin through Inhibition of Rac1-mTOR Signaling Pathway in Coronary Arterial Myocytes

Enhancement of Autophagy by Simvastatin through Inhibition of Rac1-mTOR Signaling Pathway in Coronary Arterial Myocytes

Background/Aims: In addition to their action of lowering blood cholesterol levels, statins modulate biological characteristics and functions of arterial myocytes such as viability, proliferation, apoptosis, survival and contraction. The present study tested whether simvastatin, as a prototype statin...

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Bibliographic Details
Main Authors: Yu-Miao Wei, Xiang Li, Ming Xu, Justine M. Abais, Yang Chen, Christopher R. Riebling, Krishna M. Boini, Pin-Lan Li, Yang Zhang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2013-06-01
Series:Cellular Physiology and Biochemistry
Subjects:
Simvastatin
Autophagy
mTOR
Coronary arterial myocyte
Atherosclerosis
Online Access:http://www.karger.com/Article/FullText/350111

Internet

http://www.karger.com/Article/FullText/350111

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