Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis.

Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis.

Protein tyrosine phosphatase 1B (PTP1B), a key negative regulator of leptin and insulin signaling, is positively correlated with adiposity and contributes to insulin resistance. Global PTP1B deletion improves diet-induced obesity and glucose homeostasis via enhanced leptin signaling in the brain and...

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Bibliographic Details
Main Authors: Carl Owen, Alicja Czopek, Abdelali Agouni, Louise Grant, Robert Judson, Emma K Lees, George D Mcilroy, Olga Göransson, Andy Welch, Kendra K Bence, Barbara B Kahn, Benjamin G Neel, Nimesh Mody, Mirela Delibegović
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3289674?pdf=render

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http://europepmc.org/articles/PMC3289674?pdf=render

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