Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex

Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex

The hepatitis B virus (HBV) regulatory HBx protein is required for infection, and its binding to cellular damaged DNA binding protein 1 (DDB1) is critical for this function. DDB1 is an adaptor protein for the cullin 4A Really Interesting New Gene (RING) E3 ubiquitin ligase (CRL4) complex and functio...

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Bibliographic Details
Main Authors: Marissa M. Minor, F. Blaine Hollinger, Adrienne L. McNees, Sung Yun Jung, Antrix Jain, Joseph M. Hyser, Karl-Dimiter Bissig, Betty L. Slagle
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cells
Subjects:
hepatitis B virus
HBx
damaged DNA binding protein 1
cullin 4 RING E3 ligase
SMC6
DDB1 cullin accessory factor
Online Access:https://www.mdpi.com/2073-4409/9/4/834

Internet

https://www.mdpi.com/2073-4409/9/4/834

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