Hidden suppressive interactions are common in higher-order drug combinations

Summary: The rapid increase of multi-drug resistant bacteria has led to a greater emphasis on multi-drug combination treatments. However, some combinations can be suppressive—that is, bacteria grow faster in some drug combinations than when treated with a single drug. Typically, when studying intera...

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Bibliographic Details
Main Authors: Natalie Ann Lozano-Huntelman, April Zhou, Elif Tekin, Mauricio Cruz-Loya, Bjørn Østman, Sada Boyd, Van M. Savage, Pamela Yeh
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221003230