Limited replication of yellow fever 17DD and 17D-Dengue recombinant viruses in rhesus monkeys

Limited replication of yellow fever 17DD and 17D-Dengue recombinant viruses in rhesus monkeys

For the development of safe live attenuated flavivirus vaccines one of the main properties to be established is viral replication. We have used real-time reverse transcriptase-polymerase chain reaction and virus titration by plaque assay to determine the replication of yellow fever 17DD virus (YFV 1...

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Bibliographic Details
Main Authors: Gisela F. Trindade, Renato S. Marchevsky, Ana M.B. de Fillipis, Rita M.R. Nogueira, Myrna C. Bonaldo, Pedro C. Acero, Elena Caride, Marcos S. Freire, Ricardo Galler
Format: Article
Language:English
Published: Academia Brasileira de Ciências 2008-06-01
Series:Anais da Academia Brasileira de Ciências
Subjects:
febre amarela
dengue
vacina
atenuação
replicação
RT-PCR em tempo integral
yellow fever
vaccine
attenuation
replication
real-time RT-PCR
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652008000200009

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652008000200009

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