Regulation of Proliferation by a Mitochondrial Potassium Channel in Pancreatic Ductal Adenocarcinoma Cells

Regulation of Proliferation by a Mitochondrial Potassium Channel in Pancreatic Ductal Adenocarcinoma Cells

Previous results link the mitochondrial potassium channel Kv1.3 (mitoKv1.3) to the regulation of apoptosis. By synthesizing new, mitochondria-targeted derivatives (PAPTP and PCARBTP) of PAP-1, a specific membrane-permeant Kv1.3 inhibitor, we have recently provided evidence that both drugs acting on...

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Bibliographic Details
Main Authors: Roberta Peruzzo, Andrea Mattarei, Matteo Romio, Cristina Paradisi, Mario Zoratti, Ildikò Szabò, Luigi Leanza
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Oncology
Subjects:
ion channels
mitochondria
cell cycle
ROS
pancreatic ductal adenocarcinoma
Online Access:http://journal.frontiersin.org/article/10.3389/fonc.2017.00239/full

Internet

http://journal.frontiersin.org/article/10.3389/fonc.2017.00239/full

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