Regulation of Proliferation by a Mitochondrial Potassium Channel in Pancreatic Ductal Adenocarcinoma Cells
Previous results link the mitochondrial potassium channel Kv1.3 (mitoKv1.3) to the regulation of apoptosis. By synthesizing new, mitochondria-targeted derivatives (PAPTP and PCARBTP) of PAP-1, a specific membrane-permeant Kv1.3 inhibitor, we have recently provided evidence that both drugs acting on...
Main Authors: | Roberta Peruzzo, Andrea Mattarei, Matteo Romio, Cristina Paradisi, Mario Zoratti, Ildikò Szabò, Luigi Leanza |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2017-09-01
|
Series: | Frontiers in Oncology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/article/10.3389/fonc.2017.00239/full |
Similar Items
-
Novel Mitochondria-Targeted Furocoumarin Derivatives as Possible Anti-Cancer Agents
by: Andrea Mattarei, et al.
Published: (2018-04-01) -
SYPL1 Inhibits Apoptosis in Pancreatic Ductal Adenocarcinoma via Suppression of ROS-Induced ERK Activation
by: Yunda Song, et al.
Published: (2020-09-01) -
Metastatic pancreatic ductal adenocarcinoma in a teenage girl: A rare disease
by: Sutaryo Sutaryo, et al.
Published: (2020-11-01) -
Aberrant downstream mechanisms following depletion of KMT2C and KMT2D in Pancreatic Ductal Adenocarcinoma
by: Dawkins, Joshua Benjamin Newton
Published: (2017) -
Surgical Treatment of Pancreatic Ductal Adenocarcinoma
by: Kongyuan Wei, et al.
Published: (2021-04-01)