Continuous exposure of isoprenaline inhibits myoblast differentiation and fusion through PKA/ERK1/2-FOXO1 signaling pathway

Continuous exposure of isoprenaline inhibits myoblast differentiation and fusion through PKA/ERK1/2-FOXO1 signaling pathway

Abstract Aim The objective of this study is to determine if exuberant sympathetic nerve activity is involved in muscle satellite cell differentiation and myoblast fusion. Methods and results By using immunoassaying and western blot analyses, we found that β1 and β2-adrenergic receptors (AdR) were ex...

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Bibliographic Details
Main Authors: Shao-juan Chen, Jing Yue, Jing-Xuan Zhang, Miao Jiang, Tu-qiang Hu, Wei-dong Leng, Li Xiang, Xin-yuan Li, Lei Zhang, Fei Zheng, Ye Yuan, Lin-yun Guo, Ya-mu Pan, Yu-wen Yan, Jia-ning Wang, Shi-You Chen, Jun-ming Tang
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Stem Cell Research & Therapy
Subjects:
Isoprenaline
Adrenergic receptor
Differentiation
Myoblast fusion
PKA
ERK1/2
Online Access:http://link.springer.com/article/10.1186/s13287-019-1160-x

Internet

http://link.springer.com/article/10.1186/s13287-019-1160-x

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