URMC-099 facilitates amyloid-β clearance in a murine model of Alzheimer’s disease

URMC-099 facilitates amyloid-β clearance in a murine model of Alzheimer’s disease

Abstract Background The mixed lineage kinase type 3 inhibitor URMC-099 facilitates amyloid-beta (Aβ) clearance and degradation in cultured murine microglia. One putative mechanism is an effect of URMC-099 on Aβ uptake and degradation. As URMC-099 promotes endolysosomal protein trafficking and reduce...

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Bibliographic Details
Main Authors: Tomomi Kiyota, Jatin Machhi, Yaman Lu, Bhagyalaxmi Dyavarshetty, Maryam Nemati, Gang Zhang, R. Lee Mosley, Harris A. Gelbard, Howard E. Gendelman
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Journal of Neuroinflammation
Online Access:http://link.springer.com/article/10.1186/s12974-018-1172-y

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http://link.springer.com/article/10.1186/s12974-018-1172-y

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