Targeting BRF2 in Cancer Using Repurposed Drugs

Targeting BRF2 in Cancer Using Repurposed Drugs

The overexpression of BRF2, a selective subunit of RNA polymerase III, has been shown to be crucial in the development of several types of cancers, including breast cancer and lung squamous cell carcinoma. Predominantly, BRF2 acts as a central redox-sensing transcription factor (TF) and is involved...

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Bibliographic Details
Main Authors: Behnam Rashidieh, Maryam Molakarimi, Ammar Mohseni, Simon Manuel Tria, Hein Truong, Sriganesh Srihari, Rachael C. Adams, Mathew Jones, Pascal H. G. Duijf, Murugan Kalimutho, Kum Kum Khanna
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
BRF2
cancer
molecular dynamics simulation
drug repurposing
bexarotene
Online Access:https://www.mdpi.com/2072-6694/13/15/3778

Internet

https://www.mdpi.com/2072-6694/13/15/3778

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