Detection of leukemia gene fusions by targeted RNA-sequencing in routine diagnostics

Detection of leukemia gene fusions by targeted RNA-sequencing in routine diagnostics

Abstract Background We have evaluated an NGS-based method to detect recurrent gene fusions of diagnostic and prognostic importance in hematological malignancies. Our goal was to achieve a highly specific assay with a simple workflow, short turnaround time and low cost. Method The assay uses a commer...

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Bibliographic Details
Main Authors: Marie Engvall, Nicola Cahill, Britt-Inger Jonsson, Martin Höglund, Helene Hallböök, Lucia Cavelier
Format: Article
Language:English
Published: BMC 2020-07-01
Series:BMC Medical Genomics
Subjects:
Leukemia
Gene fusion
NGS
Targeted RNA sequencing
KMT2A
Online Access:http://link.springer.com/article/10.1186/s12920-020-00739-4

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http://link.springer.com/article/10.1186/s12920-020-00739-4

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