Biomarker evidence for distal tubular damage but cortical sparing in hospitalized diabetic patients with acute kidney injury (AKI) while on SGLT2 inhibitors

Biomarker evidence for distal tubular damage but cortical sparing in hospitalized diabetic patients with acute kidney injury (AKI) while on SGLT2 inhibitors

Background Inhibitors of sodium-glucose co-transporter-2 (SGLT2i) were found to improve renal outcome in diabetic patients in large prospective randomized trials. Yet, SGLT2i may acutely reduce kidney function through volume depletion, altered glomerular hemodynamics or intensified medullary hypoxia...

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Bibliographic Details
Main Authors: Said Darawshi, Hiba Yaseen, Yuri Gorelik, Caroline Faor, Auryan Szalat, Zaid Abassi, Samuel N. Heyman, Mogher Khamaisi
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Renal Failure
Subjects:
acute kidney failure
sglt2 inhibitors
hypoxia
biomarker
ngal
kim-1
Online Access:http://dx.doi.org/10.1080/0886022X.2020.1801466

Internet

http://dx.doi.org/10.1080/0886022X.2020.1801466

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