Cyclosporine A inhibits MRTF‐SRF signaling through Na+/K+ ATPase inhibition and actin remodeling

Cyclosporine A inhibits MRTF‐SRF signaling through Na+/K+ ATPase inhibition and actin remodeling

Abstract Calcineurin inhibitors (CNI) are the pillars of immunosuppression in transplantation. However, they display a potent nephrotoxicity whose mechanisms remained widely unsolved. We used an untargeted quantitative proteomic approach (iTRAQ technology) to highlight new targets of CNI in renal pr...

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Bibliographic Details
Main Authors: Bastien Burat, Quentin Faucher, Petra Čechová, Hélène Arnion, Florent Di Meo, François‐Ludovic Sauvage, Pierre Marquet, Marie Essig
Format: Article
Language:English
Published: Wiley 2019-09-01
Series:FASEB BioAdvances
Subjects:
actin cytoskeleton
cofilin
cyclosporine A
MRTF‐SRF
Na+/K+‐ATPase
Online Access:https://doi.org/10.1096/fba.2019-00027

Internet

https://doi.org/10.1096/fba.2019-00027

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