Cyclosporine A inhibits MRTF‐SRF signaling through Na+/K+ ATPase inhibition and actin remodeling
Abstract Calcineurin inhibitors (CNI) are the pillars of immunosuppression in transplantation. However, they display a potent nephrotoxicity whose mechanisms remained widely unsolved. We used an untargeted quantitative proteomic approach (iTRAQ technology) to highlight new targets of CNI in renal pr...
Main Authors: | Bastien Burat, Quentin Faucher, Petra Čechová, Hélène Arnion, Florent Di Meo, François‐Ludovic Sauvage, Pierre Marquet, Marie Essig |
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Format: | Article |
Language: | English |
Published: |
Wiley
2019-09-01
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Series: | FASEB BioAdvances |
Subjects: | |
Online Access: | https://doi.org/10.1096/fba.2019-00027 |
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