Causal Effects of Body Mass Index on Airflow Obstruction and Forced Mid-Expiratory Flow: A Mendelian Randomization Study Taking Interactions and Age-Specific Instruments Into Consideration Toward a Life Course Perspective

Causal Effects of Body Mass Index on Airflow Obstruction and Forced Mid-Expiratory Flow: A Mendelian Randomization Study Taking Interactions and Age-Specific Instruments Into Consideration Toward a Life Course Perspective

Obesity has complex links to respiratory health. Mendelian randomization (MR) enables assessment of causality of body mass index (BMI) effects on airflow obstruction and mid-expiratory flow. In the adult SAPALDIA cohort, recruiting 9,651 population-representative samples aged 18–60 years at baseline...

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Bibliographic Details
Main Authors: Nicole Probst-Hensch, Ayoung Jeong, Daiana Stolz, Marco Pons, Paola M. Soccal, Robert Bettschart, Deborah Jarvis, John W. Holloway, Florian Kronenberg, Medea Imboden, Christian Schindler, Gianfranco F. Lovison
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Public Health
Subjects:
Mendelian randomization
body mass index
genetic score
lung function
COPD
longitudinal cohort
Online Access:https://www.frontiersin.org/articles/10.3389/fpubh.2021.584955/full

Internet

https://www.frontiersin.org/articles/10.3389/fpubh.2021.584955/full

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