Mutation-Based Antibiotic Resistance Mechanism in Methicillin-Resistant <i>Staphylococcus aureus</i> Clinical Isolates

β-Lactam antibiotics target penicillin-binding proteins and inhibit the synthesis of peptidoglycan, a crucial step in cell wall biosynthesis. <i>Staphylococcus aureus</i> acquires resistance against β-lactam antibiotics by producing a penicillin-binding protein 2a (PBP2a), encoded by the...

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Bibliographic Details
Main Authors: Tanveer Ali, Abdul Basit, Asad Mustafa Karim, Jung-Hun Lee, Jeong-Ho Jeon, Shafiq ur Rehman, Sang-Hee Lee
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Pharmaceuticals
Subjects:
Online Access:https://www.mdpi.com/1424-8247/14/5/420