Heterogeneous MAC Initiator and Pore Structures in a Lipid Bilayer by Phase-Plate Cryo-electron Tomography

Heterogeneous MAC Initiator and Pore Structures in a Lipid Bilayer by Phase-Plate Cryo-electron Tomography

Pore formation in membranes is important for mammalian immune defense against invading bacteria. Induced by complement activation, the membrane attack complex (MAC) forms through sequential binding and membrane insertion of C5b6, C7, C8, and C9. Using cryo-electron tomography with a Volta phase plat...

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Bibliographic Details
Main Authors: Thomas H. Sharp, Abraham J. Koster, Piet Gros
Format: Article
Language:English
Published: Elsevier 2016-04-01
Series:Cell Reports
Subjects:
phase plate
membrane attack complex
complement
electron tomography
subtomogram average
membrane pore
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716302261

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http://www.sciencedirect.com/science/article/pii/S2211124716302261

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