The anorectic actions of the TGFβ cytokine MIC-1/GDF15 require an intact brainstem area postrema and nucleus of the solitary tract.
Macrophage inhibitory cytokine-1 (MIC-1/GDF15) modulates food intake and body weight under physiological and pathological conditions by acting on the hypothalamus and brainstem. When overexpressed in disease, such as in advanced cancer, elevated serum MIC-1/GDF15 levels lead to an anorexia/cachexia...
Main Authors: | Vicky Wang-Wei Tsai, Rakesh Manandhar, Sebastian Beck Jørgensen, Ka Ki Michelle Lee-Ng, Hong Ping Zhang, Christopher Peter Marquis, Lele Jiang, Yasmin Husaini, Shu Lin, Amanda Sainsbury, Paul E Sawchenko, David A Brown, Samuel N Breit |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4074070?pdf=render |
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