Point mutations in the transmembrane region of the clic1 ion channel selectively modify its biophysical properties.

by Stefania Averaimo, Rosella Abeti, Nicoletta Savalli, Louise J Brown, Paul M G Curmi, Samuel N Breit, Michele Mazzanti
Published 2013-01-01

First Behavioural Characterisation of a Knockout Mouse Model for the Transforming Growth Factor (TGF)-β Superfamily Cytokine, MIC-1/GDF15.

by Jac Kee Low, Ananthan Ambikairajah, Kani Shang, David A Brown, Vicky W W Tsai, Samuel N Breit, Tim Karl
Published 2017-01-01

Macrophage inhibitory cytokine-1 (MIC-1/GDF15) gene deletion promotes cancer growth in TRAMP prostate cancer prone mice.

by Yasmin Husaini, Glen P Lockwood, Trung V Nguyen, Vicky Wang-Wei Tsai, Mohammad G Mohammad, Pamela J Russell, David A Brown, Samuel N Breit
Published 2015-01-01

CLIC1 regulates dendritic cell antigen processing and presentation by modulating phagosome acidification and proteolysis

by Kanin Salao, Lele Jiang, Hui Li, Vicky W.-W. Tsai, Yasmin Husaini, Paul M. G. Curmi, Louise J. Brown, David A. Brown, Samuel N. Breit
Published 2016-05-01

Growth differentiation factor-15 slows the growth of murine prostate cancer by stimulating tumor immunity.

by Yasmin Husaini, Vicky Wang-Wei Tsai, Rakesh Manandhar, Hong Ping Zhang, Ka Ki Michelle Lee-Ng, Hélène Lebhar, Christopher P Marquis, David A Brown, Samuel N Breit
Published 2020-01-01

Macrophage inhibitory cytokine 1 (MIC-1/GDF15) decreases food intake, body weight and improves glucose tolerance in mice on normal & obesogenic diets.

by Laurence Macia, Vicky Wang-Wei Tsai, Amy D Nguyen, Heiko Johnen, Tamara Kuffner, Yan-Chuan Shi, Shu Lin, Herbert Herzog, David A Brown, Samuel N Breit, Amanda Sainsbury
Published 2012-01-01

The relationship of serum macrophage inhibitory cytokine-1 levels with gray matter volumes in community-dwelling older individuals.

by Jiyang Jiang, Wei Wen, David A Brown, John Crawford, Anbupalam Thalamuthu, Evelyn Smith, Samuel N Breit, Tao Liu, Wanlin Zhu, Henry Brodaty, Bernhard T Baune, Julian N Trollor, Perminder S Sachdev
Published 2015-01-01

Associations of serum short-chain fatty acids with circulating immune cells and serum biomarkers in patients with multiple sclerosis

by Stephanie Trend, Jonatan Leffler, Anderson P. Jones, Lilian Cha, Shelley Gorman, David A. Brown, Samuel N. Breit, Allan G. Kermode, Martyn A. French, Natalie C. Ward, Prue H. Hart
Published 2021-03-01

Macrophage inhibitory cytokine-1 (MIC-1/GDF15) slows cancer development but increases metastases in TRAMP prostate cancer prone mice.

by Yasmin Husaini, Min Ru Qiu, Glen P Lockwood, Xu Wei Luo, Ping Shang, Tamara Kuffner, Vicky Wang-Wei Tsai, Lele Jiang, Pamela J Russell, David A Brown, Samuel N Breit
Published 2012-01-01

Dendritic Cells and Multiple Sclerosis: Disease, Tolerance and Therapy

by Mohammad G. Mohammad, Masoud Hassanpour, Vicky W. W. Tsai, Hui Li, Marc J. Ruitenberg, David R. Booth, Jordi Serrats, Prue H. Hart, Geoffrey P. Symonds, Paul E. Sawchenko, Samuel N. Breit, David A. Brown
Published 2012-12-01

The anorectic actions of the TGFβ cytokine MIC-1/GDF15 require an intact brainstem area postrema and nucleus of the solitary tract.

by Vicky Wang-Wei Tsai, Rakesh Manandhar, Sebastian Beck Jørgensen, Ka Ki Michelle Lee-Ng, Hong Ping Zhang, Christopher Peter Marquis, Lele Jiang, Yasmin Husaini, Shu Lin, Amanda Sainsbury, Paul E Sawchenko, David A Brown, Samuel N Breit
Published 2014-01-01

TGF-b superfamily cytokine MIC-1/GDF15 is a physiological appetite and body weight regulator.

by Vicky Wang-Wei Tsai, Laurence Macia, Heiko Johnen, Tamara Kuffner, Rakesh Manadhar, Sebastian Beck Jørgensen, Ka Ki Michelle Lee-Ng, Hong Ping Zhang, Liyun Wu, Christopher Peter Marquis, Lele Jiang, Yasmin Husaini, Shu Lin, Herbert Herzog, David A Brown, Amanda Sainsbury, Samuel N Breit
Published 2013-01-01

Serum Levels of Human MIC-1/GDF15 Vary in a Diurnal Pattern, Do Not Display a Profile Suggestive of a Satiety Factor and Are Related to BMI.

by Vicky Wang-Wei Tsai, Laurence Macia, Christine Feinle-Bisset, Rakesh Manandhar, Arne Astrup, Anne Raben, Janne Kunchel Lorenzen, Peter T Schmidt, Fredrik Wiklund, Nancy L Pedersen, Lesley Campbell, Adamandia Kriketos, Aimin Xu, Zhou Pengcheng, Weiping Jia, Paul M G Curmi, Christopher N Angstmann, Ka Ki Michelle Lee-Ng, Hong Ping Zhang, Christopher P Marquis, Yasmin Husaini, Christoph Beglinger, Shu Lin, Herbert Herzog, David A Brown, Amanda Sainsbury, Samuel N Breit
Published 2015-01-01

A Meta-Analysis of Genome-Wide Association Studies of Growth Differentiation Factor-15 Concentration in Blood

by Jiyang Jiang, Anbupalam Thalamuthu, Jennifer E. Ho, Jennifer E. Ho, Anubha Mahajan, Weronica E. Ek, David A. Brown, David A. Brown, Samuel N. Breit, Thomas J. Wang, Ulf Gyllensten, Ming-Huei Chen, Ming-Huei Chen, Stefan Enroth, James L. Januzzi, Lars Lind, Nicola J. Armstrong, Nicola J. Armstrong, John B. Kwok, John B. Kwok, Peter R. Schofield, Peter R. Schofield, Wei Wen, Wei Wen, Julian N. Trollor, Julian N. Trollor, Åsa Johansson, Andrew P. Morris, Andrew P. Morris, Ramachandran S. Vasan, Ramachandran S. Vasan, Perminder S. Sachdev, Perminder S. Sachdev, Karen A. Mather
Published 2018-03-01