Genome-Wide Association Studies of Estimated Fatty Acid Desaturase Activity in Serum and Adipose Tissue in Elderly Individuals: Associations with Insulin Sensitivity

by Matti Marklund, Andrew P. Morris, Anubha Mahajan, Erik Ingelsson, Cecilia M. Lindgren, Lars Lind, Ulf Risérus
Published 2018-11-01

Common variants in CRP and LEPR influence high sensitivity C-reactive protein levels in North Indians.

by Anubha Mahajan, Rubina Tabassum, Sreenivas Chavali, Om Prakash Dwivedi, Ganesh Chauhan, Saurabh Ghosh, Nikhil Tandon, Dwaipayan Bharadwaj
Published 2011-01-01

Homogeneity in the association of body mass index with type 2 diabetes across the UK Biobank: A Mendelian randomization study.

by Michael Wainberg, Anubha Mahajan, Anshul Kundaje, Mark I McCarthy, Erik Ingelsson, Nasa Sinnott-Armstrong, Manuel A Rivas
Published 2019-12-01

Genetic and methylation variation in the CYP2B6 gene is related to circulating p,p′-dde levels in a population-based sample

by Lars Lind, Esther Ng, Erik Ingelsson, Cecilia Lindgren, Samira Salihovic, Bert van Bavel, Anubha Mahajan, Erik Lampa, Andrew P. Morris, P. Monica Lind
Published 2017-01-01

Deep learning models predict regulatory variants in pancreatic islets and refine type 2 diabetes association signals

by Agata Wesolowska-Andersen, Grace Zhuo Yu, Vibe Nylander, Fernando Abaitua, Matthias Thurner, Jason M Torres, Anubha Mahajan, Anna L Gloyn, Mark I McCarthy
Published 2020-01-01

Causal relationships between obesity and the leading causes of death in women and men.

by Jenny C Censin, Sanne A E Peters, Jonas Bovijn, Teresa Ferreira, Sara L Pulit, Reedik Mägi, Anubha Mahajan, Michael V Holmes, Cecilia M Lindgren
Published 2019-10-01

Developing a network view of type 2 diabetes risk pathways through integration of genetic, genomic and functional data

by Juan Fernández-Tajes, Kyle J. Gaulton, Martijn van de Bunt, Jason Torres, Matthias Thurner, Anubha Mahajan, Anna L. Gloyn, Kasper Lage, Mark I. McCarthy
Published 2019-03-01

Bone mineral density and risk of type 2 diabetes and coronary heart disease: A Mendelian randomization study [version 1; referees: 2 approved, 1 approved with reservations]

by Wei Gan, Robert J. Clarke, Anubha Mahajan, Benard Kulohoma, Hidetoshi Kitajima, Neil R. Robertson, N. William Rayner, Robin G. Walters, Michael V. Holmes, Zhengming Chen, Mark I. McCarthy
Published 2017-08-01

Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci

by Matthias Thurner, Martijn van de Bunt, Jason M Torres, Anubha Mahajan, Vibe Nylander, Amanda J Bennett, Kyle J Gaulton, Amy Barrett, Carla Burrows, Christopher G Bell, Robert Lowe, Stephan Beck, Vardhman K Rakyan, Anna L Gloyn, Mark I McCarthy
Published 2018-02-01

Association of vitamin D with risk of type 2 diabetes: A Mendelian randomisation study in European and Chinese adults.

by Ling Lu, Derrick A Bennett, Iona Y Millwood, Sarah Parish, Mark I McCarthy, Anubha Mahajan, Xu Lin, Fiona Bragg, Yu Guo, Michael V Holmes, Shoaib Afzal, Børge G Nordestgaard, Zheng Bian, Michael Hill, Robin G Walters, Liming Li, Zhengming Chen, Robert Clarke
Published 2018-05-01

RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro

by Nellie Y. Loh, James E. N. Minchin, Katherine E. Pinnick, Manu Verma, Marijana Todorčević, Nathan Denton, Julia El-Sayed Moustafa, John P. Kemp, Celia L. Gregson, David M. Evans, Matt J. Neville, Kerrin S. Small, Mark I. McCarthy, Anubha Mahajan, John F. Rawls, Fredrik Karpe, Constantinos Christodoulides
Published 2020-06-01

Effects of apolipoprotein B on lifespan and risks of major diseases including type 2 diabetes: a mendelian randomisation analysis using outcomes in first-degree relatives

by Tom G Richardson, PhD, Qin Wang, PhD, Eleanor Sanderson, PhD, Anubha Mahajan, PhD, Mark I McCarthy, ProfMD, Timothy M Frayling, ProfPhD, Mika Ala-Korpela, ProfPhD, Allan Sniderman, ProfMD, George Davey Smith, ProfFRS, Michael V Holmes, MD
Published 2021-06-01

Habitual coffee consumption and cognitive function: a Mendelian randomization meta-analysis in up to 415,530 participants

by Ang Zhou, Amy E. Taylor, Ville Karhunen, Yiqiang Zhan, Suvi P. Rovio, Jari Lahti, Per Sjögren, Liisa Byberg, Donald M. Lyall, Juha Auvinen, Terho Lehtimäki, Mika Kähönen, Nina Hutri-Kähönen, Mia Maria Perälä, Karl Michaëlsson, Anubha Mahajan, Lars Lind, Chris Power, Johan G. Eriksson, Olli T. Raitakari, Sara Hägg, Nancy L. Pedersen, Juha Veijola, Marjo-Riitta Järvelin, Marcus R. Munafò, Erik Ingelsson, David J. Llewellyn, Elina Hyppönen
Published 2018-05-01

Integrative network analysis highlights biological processes underlying GLP-1 stimulated insulin secretion: A DIRECT study.

by Valborg Gudmundsdottir, Helle Krogh Pedersen, Karla Viviani Allebrandt, Caroline Brorsson, Nienke van Leeuwen, Karina Banasik, Anubha Mahajan, Christopher J Groves, Martijn van de Bunt, Adem Y Dawed, Andreas Fritsche, Harald Staiger, Annemarie M C Simonis-Bik, Joris Deelen, Mark H H Kramer, Axel Dietrich, Thomas Hübschle, Gonneke Willemsen, Hans-Ulrich Häring, Eco J C de Geus, Dorret I Boomsma, Elisabeth M W Eekhoff, Jorge Ferrer, Mark I McCarthy, Ewan R Pearson, Ramneek Gupta, Søren Brunak, Leen M 't Hart
Published 2018-01-01

Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk: An IMI DIRECT study

by Rebeca Eriksen, Isabel Garcia Perez, Joram M. Posma, Mark Haid, Sapna Sharma, Cornelia Prehn, Louise E. Thomas, Robert W. Koivula, Roberto Bizzotto, Cornelia Prehn, Andrea Mari, Giuseppe N. Giordano, Imre Pavo, Jochen M. Schwenk, Federico De Masi, Konstantinos D. Tsirigos, Søren Brunak, Ana Viñuela, Anubha Mahajan, Timothy J. McDonald, Tarja Kokkola, Femke Rutter, Harriet Teare, Tue H. Hansen, Juan Fernandez, Angus Jones, Chris Jennison, Mark Walker, Mark I. McCarthy, Oluf Pedersen, Hartmut Ruetten, Ian Forgie, Jimmy D. Bell, Ewan R. Pearson, Paul W. Franks, Jerzy Adamski, Elaine Holmes, Gary Frost
Published 2020-08-01

A Meta-Analysis of Genome-Wide Association Studies of Growth Differentiation Factor-15 Concentration in Blood

by Jiyang Jiang, Anbupalam Thalamuthu, Jennifer E. Ho, Jennifer E. Ho, Anubha Mahajan, Weronica E. Ek, David A. Brown, David A. Brown, Samuel N. Breit, Thomas J. Wang, Ulf Gyllensten, Ming-Huei Chen, Ming-Huei Chen, Stefan Enroth, James L. Januzzi, Lars Lind, Nicola J. Armstrong, Nicola J. Armstrong, John B. Kwok, John B. Kwok, Peter R. Schofield, Peter R. Schofield, Wei Wen, Wei Wen, Julian N. Trollor, Julian N. Trollor, Åsa Johansson, Andrew P. Morris, Andrew P. Morris, Ramachandran S. Vasan, Ramachandran S. Vasan, Perminder S. Sachdev, Perminder S. Sachdev, Karen A. Mather
Published 2018-03-01

Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D

by Ana Viñuela, Arushi Varshney, Martijn van de Bunt, Rashmi B. Prasad, Olof Asplund, Amanda Bennett, Michael Boehnke, Andrew A. Brown, Michael R. Erdos, João Fadista, Ola Hansson, Gad Hatem, Cédric Howald, Apoorva K. Iyengar, Paul Johnson, Ulrika Krus, Patrick E. MacDonald, Anubha Mahajan, Jocelyn E. Manning Fox, Narisu Narisu, Vibe Nylander, Peter Orchard, Nikolay Oskolkov, Nikolaos I. Panousis, Anthony Payne, Michael L. Stitzel, Swarooparani Vadlamudi, Ryan Welch, Francis S. Collins, Karen L. Mohlke, Anna L. Gloyn, Laura J. Scott, Emmanouil T. Dermitzakis, Leif Groop, Stephen C. J. Parker, Mark I. McCarthy
Published 2020-09-01

Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study.

by Morgan Obura, Joline W J Beulens, Roderick Slieker, Anitra D M Koopman, Trynke Hoekstra, Giel Nijpels, Petra Elders, Robert W Koivula, Azra Kurbasic, Markku Laakso, Tue H Hansen, Martin Ridderstråle, Torben Hansen, Imre Pavo, Ian Forgie, Bernd Jablonka, Hartmut Ruetten, Andrea Mari, Mark I McCarthy, Mark Walker, Alison Heggie, Timothy J McDonald, Mandy H Perry, Federico De Masi, Søren Brunak, Anubha Mahajan, Giuseppe N Giordano, Tarja Kokkola, Emmanouil Dermitzakis, Ana Viñuela, Oluf Pedersen, Jochen M Schwenk, Jurek Adamski, Harriet J A Teare, Ewan R Pearson, Paul W Franks, Leen M 't Hart, Femke Rutters, IMI-DIRECT Consortium
Published 2020-01-01

Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria.

by Felix Day, Tugce Karaderi, Michelle R Jones, Cindy Meun, Chunyan He, Alex Drong, Peter Kraft, Nan Lin, Hongyan Huang, Linda Broer, Reedik Magi, Richa Saxena, Triin Laisk, Margrit Urbanek, M Geoffrey Hayes, Gudmar Thorleifsson, Juan Fernandez-Tajes, Anubha Mahajan, Benjamin H Mullin, Bronwyn G A Stuckey, Timothy D Spector, Scott G Wilson, Mark O Goodarzi, Lea Davis, Barbara Obermayer-Pietsch, André G Uitterlinden, Verneri Anttila, Benjamin M Neale, Marjo-Riitta Jarvelin, Bart Fauser, Irina Kowalska, Jenny A Visser, Marianne Andersen, Ken Ong, Elisabet Stener-Victorin, David Ehrmann, Richard S Legro, Andres Salumets, Mark I McCarthy, Laure Morin-Papunen, Unnur Thorsteinsdottir, Kari Stefansson, 23andMe Research Team, Unnur Styrkarsdottir, John R B Perry, Andrea Dunaif, Joop Laven, Steve Franks, Cecilia M Lindgren, Corrine K Welt
Published 2018-12-01

Correction: Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria.

by Felix Day, Tugce Karaderi, Michelle R Jones, Cindy Meun, Chunyan He, Alex Drong, Peter Kraft, Nan Lin, Hongyan Huang, Linda Broer, Reedik Magi, Richa Saxena, Triin Laisk, Margrit Urbanek, M Geoffrey Hayes, Gudmar Thorleifsson, Juan Fernandez-Tajes, Anubha Mahajan, Benjamin H Mullin, Bronwyn G A Stuckey, Timothy D Spector, Scott G Wilson, Mark O Goodarzi, Lea Davis, Barbara Obermayer-Pietsch, André G Uitterlinden, Verneri Anttila, Benjamin M Neale, Marjo-Riitta Jarvelin, Bart Fauser, Irina Kowalska, Jenny A Visser, Marianne Andersen, Ken Ong, Elisabet Stener-Victorin, David Ehrmann, Richard S Legro, Andres Salumets, Mark I McCarthy, Laure Morin-Papunen, Unnur Thorsteinsdottir, Kari Stefansson, 23andMe Research Team, Unnur Styrkarsdottir, John R B Perry, Andrea Dunaif, Joop Laven, Steve Franks, Cecilia M Lindgren, Corrine K Welt
Published 2019-12-01