Integrating comprehensive functional annotations to boost power and accuracy in gene-based association analysis.

by Corbin Quick, Xiaoquan Wen, Gonçalo Abecasis, Michael Boehnke, Hyun Min Kang
Published 2020-12-01

The Metabolic Syndrome in Men study: a resource for studies of metabolic and cardiovascular diseases

by Markku Laakso, Johanna Kuusisto, Alena Stančáková, Teemu Kuulasmaa, Päivi Pajukanta, Aldons J. Lusis, Francis S. Collins, Karen L. Mohlke, Michael Boehnke
Published 2017-03-01

Extremely rare variants reveal patterns of germline mutation rate heterogeneity in humans

by Jedidiah Carlson, Adam E. Locke, Matthew Flickinger, Matthew Zawistowski, Shawn Levy, Richard M. Myers, Michael Boehnke, Hyun Min Kang, Laura J. Scott, Jun Z. Li, Sebastian Zöllner, The BRIDGES Consortium
Published 2018-09-01

Imputation-Aware Tag SNP Selection To Improve Power for Large-Scale, Multi-ethnic Association Studies

by Genevieve L. Wojcik, Christian Fuchsberger, Daniel Taliun, Ryan Welch, Alicia R Martin, Suyash Shringarpure, Christopher S. Carlson, Goncalo Abecasis, Hyun Min Kang, Michael Boehnke, Carlos D. Bustamante, Christopher R. Gignoux, Eimear E. Kenny
Published 2018-10-01

The power of gene-based rare variant methods to detect disease-associated variation and test hypotheses about complex disease.

by Loukas Moutsianas, Vineeta Agarwala, Christian Fuchsberger, Jason Flannick, Manuel A Rivas, Kyle J Gaulton, Patrick K Albers, GoT2D Consortium, Gil McVean, Michael Boehnke, David Altshuler, Mark I McCarthy
Published 2015-04-01

Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia.

by Xueling Sim, Rick Twee-Hee Ong, Chen Suo, Wan-Ting Tay, Jianjun Liu, Daniel Peng-Keat Ng, Michael Boehnke, Kee-Seng Chia, Tien-Yin Wong, Mark Seielstad, Yik-Ying Teo, E-Shyong Tai
Published 2011-04-01

Novel association of TM6SF2 rs58542926 genotype with increased serum tyrosine levels and decreased apoB-100 particles in Finns

by Daniel Seung Kim, Anne U. Jackson, Yatong K. Li, Heather M. Stringham, Johanna Kuusisto, Antti J. Kangas, Pasi Soininen, Mika Ala-Korpela, Charles F. Burant, Veikko Salomaa, Michael Boehnke, Markku Laakso, Elizabeth K. Speliotes
Published 2017-07-01

Trans-ancestry Fine Mapping and Molecular Assays Identify Regulatory Variants at the ANGPTL8 HDL-C GWAS Locus

by Maren E. Cannon, Qing Duan, Ying Wu, Monica Zeynalzadeh, Zheng Xu, Antti J. Kangas, Pasi Soininen, Mika Ala-Korpela, Mete Civelek, Aldons J. Lusis, Johanna Kuusisto, Francis S. Collins, Michael Boehnke, Hua Tang, Markku Laakso, Yun Li, Karen L. Mohlke
Published 2017-09-01

Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis.

by Miriam S Udler, Jaegil Kim, Marcin von Grotthuss, Sílvia Bonàs-Guarch, Joanne B Cole, Joshua Chiou, Christopher D. Anderson on behalf of METASTROKE and the ISGC, Michael Boehnke, Markku Laakso, Gil Atzmon, Benjamin Glaser, Josep M Mercader, Kyle Gaulton, Jason Flannick, Gad Getz, Jose C Florez
Published 2018-09-01

Common variants show predicted polygenic effects on height in the tails of the distribution, except in extremely short individuals.

by Yingleong Chan, Oddgeir L Holmen, Andrew Dauber, Lars Vatten, Aki S Havulinna, Frank Skorpen, Kirsti Kvaløy, Kaisa Silander, Thutrang T Nguyen, Cristen Willer, Michael Boehnke, Markus Perola, Aarno Palotie, Veikko Salomaa, Kristian Hveem, Timothy M Frayling, Joel N Hirschhorn, Michael N Weedon
Published 2011-12-01

Author Correction: Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS

by David Z. Pan, Kristina M. Garske, Marcus Alvarez, Yash V. Bhagat, James Boocock, Elina Nikkola, Zong Miao, Chelsea K. Raulerson, Rita M. Cantor, Mete Civelek, Craig A. Glastonbury, Kerrin S. Small, Michael Boehnke, Aldons J. Lusis, Janet S. Sinsheimer, Karen L. Mohlke, Markku Laakso, Päivi Pajukanta, Arthur Ko
Published 2018-08-01

Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS

by David Z. Pan, Kristina M. Garske, Marcus Alvarez, Yash V. Bhagat, James Boocock, Elina Nikkola, Zong Miao, Chelsea K. Raulerson, Rita M. Cantor, Mete Civelek, Craig A. Glastonbury, Kerrin S. Small, Michael Boehnke, Aldons J. Lusis, Janet S. Sinsheimer, Karen L. Mohlke, Markku Laakso, Päivi Pajukanta, Arthur Ko
Published 2018-04-01

Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study.

by James P Davis, Jeroen R Huyghe, Adam E Locke, Anne U Jackson, Xueling Sim, Heather M Stringham, Tanya M Teslovich, Ryan P Welch, Christian Fuchsberger, Narisu Narisu, Peter S Chines, Antti J Kangas, Pasi Soininen, Mika Ala-Korpela, Johanna Kuusisto, Francis S Collins, Markku Laakso, Michael Boehnke, Karen L Mohlke
Published 2017-10-01

Association Analysis and Meta-Analysis of Multi-Allelic Variants for Large-Scale Sequence Data

by Yu Jiang, Sai Chen, Xingyan Wang, Mengzhen Liu, William G. Iacono, John K. Hewitt, John E. Hokanson, Kenneth Krauter, Markku Laakso, Kevin W. Li, Sharon M. Lutz, Matthew McGue, Anita Pandit, Gregory J.M. Zajac, Michael Boehnke, Goncalo R. Abecasis, Scott I. Vrieze, Bibo Jiang, Xiaowei Zhan, Dajiang J. Liu
Published 2020-05-01

Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences

by Liron Ganel, Lei Chen, Ryan Christ, Jagadish Vangipurapu, Erica Young, Indraniel Das, Krishna Kanchi, David Larson, Allison Regier, Haley Abel, Chul Joo Kang, Alexandra Scott, Aki Havulinna, Charleston W. K. Chiang, Susan Service, Nelson Freimer, Aarno Palotie, Samuli Ripatti, Johanna Kuusisto, Michael Boehnke, Markku Laakso, Adam Locke, Nathan O. Stitziel, Ira M. Hall
Published 2021-06-01

Proper conditional analysis in the presence of missing data: Application to large scale meta-analysis of tobacco use phenotypes.

by Yu Jiang, Sai Chen, Daniel McGuire, Fang Chen, Mengzhen Liu, William G Iacono, John K Hewitt, John E Hokanson, Kenneth Krauter, Markku Laakso, Kevin W Li, Sharon M Lutz, Matthew McGue, Anita Pandit, Gregory J M Zajac, Michael Boehnke, Goncalo R Abecasis, Scott I Vrieze, Xiaowei Zhan, Bibo Jiang, Dajiang J Liu
Published 2018-07-01

Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability.

by Serena Sanna, Bingshan Li, Antonella Mulas, Carlo Sidore, Hyun M Kang, Anne U Jackson, Maria Grazia Piras, Gianluca Usala, Giuseppe Maninchedda, Alessandro Sassu, Fabrizio Serra, Maria Antonietta Palmas, William H Wood, Inger Njølstad, Markku Laakso, Kristian Hveem, Jaakko Tuomilehto, Timo A Lakka, Rainer Rauramaa, Michael Boehnke, Francesco Cucca, Manuela Uda, David Schlessinger, Ramaiah Nagaraja, Gonçalo R Abecasis
Published 2011-07-01

Adiponectin GWAS loci harboring extensive allelic heterogeneity exhibit distinct molecular consequences.

by Cassandra N Spracklen, Apoorva K Iyengar, Swarooparani Vadlamudi, Chelsea K Raulerson, Anne U Jackson, Sarah M Brotman, Ying Wu, Maren E Cannon, James P Davis, Aaron T Crain, Kevin W Currin, Hannah J Perrin, Narisu Narisu, Heather M Stringham, Christian Fuchsberger, Adam E Locke, Ryan P Welch, Johanna K Kuusisto, Päivi Pajukanta, Laura J Scott, Yun Li, Francis S Collins, Michael Boehnke, Markku Laakso, Karen L Mohlke
Published 2020-09-01

Interactions between genetic variation and cellular environment in skeletal muscle gene expression.

by D Leland Taylor, David A Knowles, Laura J Scott, Andrea H Ramirez, Francesco Paolo Casale, Brooke N Wolford, Li Guan, Arushi Varshney, Ricardo D'Oliveira Albanus, Stephen C J Parker, Narisu Narisu, Peter S Chines, Michael R Erdos, Ryan P Welch, Leena Kinnunen, Jouko Saramies, Jouko Sundvall, Timo A Lakka, Markku Laakso, Jaakko Tuomilehto, Heikki A Koistinen, Oliver Stegle, Michael Boehnke, Ewan Birney, Francis S Collins
Published 2018-01-01

The genetic regulatory signature of type 2 diabetes in human skeletal muscle

by Laura J. Scott, Michael R. Erdos, Jeroen R. Huyghe, Ryan P. Welch, Andrew T. Beck, Brooke N. Wolford, Peter S. Chines, John P. Didion, Narisu Narisu, Heather M. Stringham, D. Leland Taylor, Anne U. Jackson, Swarooparani Vadlamudi, Lori L. Bonnycastle, Leena Kinnunen, Jouko Saramies, Jouko Sundvall, Ricardo D'Oliveira Albanus, Anna Kiseleva, John Hensley, Gregory E. Crawford, Hui Jiang, Xiaoquan Wen, Richard M. Watanabe, Timo A. Lakka, Karen L. Mohlke, Markku Laakso, Jaakko Tuomilehto, Heikki A. Koistinen, Michael Boehnke, Francis S. Collins, Stephen C. J. Parker
Published 2016-06-01