Haplotype heterogeneity and low linkage disequilibrium reduce reliable prediction of genotypes for the ‑α3.7I form of α-thalassaemia using genome-wide microarray data [version 2; peer review: 2 approved]

Haplotype heterogeneity and low linkage disequilibrium reduce reliable prediction of genotypes for the ‑α3.7I form of α-thalassaemia using genome-wide microarray data [version 2; peer review: 2 approved]

Background: The -α3.7I-thalassaemia deletion is very common throughout Africa because it protects against malaria. When undertaking studies to investigate human genetic adaptations to malaria or other diseases, it is important to account for any confounding effects of α-thalassaemia to rule out spur...

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Bibliographic Details
Main Authors: Carolyne M. Ndila, Vysaul Nyirongo, Alexander W. Macharia, Anna E. Jeffreys, Kate Rowlands, Christina Hubbart, George B. J. Busby, Gavin Band, Rosalind M. Harding, Kirk A. Rockett, Thomas N. Williams, MalariaGEN Consortium
Format: Article
Language:English
Published: Wellcome 2021-09-01
Series:Wellcome Open Research
Online Access:https://wellcomeopenresearch.org/articles/5-287/v2

Internet

https://wellcomeopenresearch.org/articles/5-287/v2

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